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	<title>hypomethylation &#8211; BIOENGINEER.ORG</title>
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		<title>MiR-145 emerges as a driver and biomarker of the fibrotic tumor microenvironment</title>
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		<pubDate>Mon, 19 Oct 2026 10:35:02 +0000</pubDate>
				<category><![CDATA[Biology]]></category>
		<category><![CDATA[Cancer-associated fibroblasts]]></category>
		<category><![CDATA[EMT]]></category>
		<category><![CDATA[facilitates]]></category>
		<category><![CDATA[Fibrosis]]></category>
		<category><![CDATA[GAPDH]]></category>
		<category><![CDATA[hypomethylation]]></category>
		<category><![CDATA[immune evasion]]></category>
		<category><![CDATA[miR-145]]></category>
		<category><![CDATA[mitochondrial metabolism]]></category>
		<category><![CDATA[Notch Signaling]]></category>
		<category><![CDATA[reprogramming]]></category>
		<category><![CDATA[tumor microenvironment]]></category>
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					<description><![CDATA[A new study identifies miR-145 as a driver and biomarker of the fibrotic tumor microenvironment, linking NOTCH signaling, promoter hypomethylation, enhanced mitochondrial metabolism, and immune evasion to poor clinical outcomes in HNSCC and breast cancer.]]></description>
		
		
		
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