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	<title>hereditary deafness &#8211; BIOENGINEER.ORG</title>
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		<title>Misfolded Proteins May Explain a Hidden Share of Inherited Deafness</title>
		<link>https://bioengineer.org/misfolded-proteins-may-explain-a-hidden-share-of-inherited-deafness/</link>
		
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		<pubDate>Thu, 08 Oct 2026 18:03:08 +0000</pubDate>
				<category><![CDATA[Biology]]></category>
		<category><![CDATA[ACMG/AMP guidelines]]></category>
		<category><![CDATA[Bayesian model]]></category>
		<category><![CDATA[Deafness Variation Database]]></category>
		<category><![CDATA[genetic diagnosis]]></category>
		<category><![CDATA[hair cells]]></category>
		<category><![CDATA[hereditary deafness]]></category>
		<category><![CDATA[missense variants]]></category>
		<category><![CDATA[PLOS Genetics]]></category>
		<category><![CDATA[protein misfolding]]></category>
		<category><![CDATA[Protein Stability]]></category>
		<category><![CDATA[variant interpretation]]></category>
		<category><![CDATA[variant of uncertain significance]]></category>
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					<description><![CDATA[A large-scale computational study finds that protein misfolding may underlie a substantial share of hereditary hearing loss, reclassifying tens of thousands of uncertain variants and upgrading twelve patient diagnoses.]]></description>
		
		
		
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