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	<title>H-box &#8211; BIOENGINEER.ORG</title>
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	<title>H-box &#8211; BIOENGINEER.ORG</title>
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		<title>Virtual screen of 12 million compounds yields new bacterial kinase inhibitors</title>
		<link>https://bioengineer.org/virtual-screen-of-12-million-compounds-yields-new-bacterial-kinase-inhibitors/</link>
		
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		<pubDate>Thu, 08 Oct 2026 11:01:14 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[amino acid mapping]]></category>
		<category><![CDATA[antibiotic resistance]]></category>
		<category><![CDATA[drug discovery]]></category>
		<category><![CDATA[H-box]]></category>
		<category><![CDATA[histidine kinase]]></category>
		<category><![CDATA[molecular dynamics]]></category>
		<category><![CDATA[NMR]]></category>
		<category><![CDATA[pyridopyrimidinone]]></category>
		<category><![CDATA[Scaffold hopping]]></category>
		<category><![CDATA[two-component system]]></category>
		<category><![CDATA[virtual screening]]></category>
		<category><![CDATA[waldiomycin]]></category>
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					<description><![CDATA[Japanese researchers used an amino acid mapping descriptor derived from the natural antibiotic waldiomycin to screen nearly 12 million compounds and identified three novel pyridopyrimidinone inhibitors of bacterial histidine kinases that target the conserved H-box region.]]></description>
		
		
		
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