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		<title>Lactate Tag on Histones Fuels Drug Resistance in Head and Neck Cancer</title>
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		<pubDate>Mon, 05 Oct 2026 17:27:04 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[cancer metabolism]]></category>
		<category><![CDATA[CBP]]></category>
		<category><![CDATA[EGFR]]></category>
		<category><![CDATA[epigenetics]]></category>
		<category><![CDATA[gefitinib resistance]]></category>
		<category><![CDATA[GLI2]]></category>
		<category><![CDATA[GLUT3]]></category>
		<category><![CDATA[H3K18la]]></category>
		<category><![CDATA[head and neck squamous cell carcinoma]]></category>
		<category><![CDATA[Histone lactylation]]></category>
		<category><![CDATA[lactate]]></category>
		<category><![CDATA[targeted therapy]]></category>
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					<description><![CDATA[New research shows that CBP-driven histone H3K18 lactylation activates GLI2 transcription, promoting head and neck squamous cell carcinoma progression and resistance to EGFR-targeted therapies such as gefitinib.]]></description>
		
		
		
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