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	<title>FHL-1 &#8211; BIOENGINEER.ORG</title>
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		<title>One Gene, Two Proteins: Why CFH Cancer Biomarker Studies May Be Measuring the Wrong Molecule</title>
		<link>https://bioengineer.org/one-gene-two-proteins-why-cfh-cancer-biomarker-studies-may-be-measuring-the-wrong-molecule/</link>
		
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		<pubDate>Sun, 11 Oct 2026 06:01:29 +0000</pubDate>
				<category><![CDATA[Cancer]]></category>
		<category><![CDATA[alternative splicing]]></category>
		<category><![CDATA[biomarkers]]></category>
		<category><![CDATA[CFH]]></category>
		<category><![CDATA[complement factor H]]></category>
		<category><![CDATA[complement system]]></category>
		<category><![CDATA[extracellular matrix]]></category>
		<category><![CDATA[FHL-1]]></category>
		<category><![CDATA[immunotherapy]]></category>
		<category><![CDATA[Pan-cancer analysis]]></category>
		<category><![CDATA[prognosis]]></category>
		<category><![CDATA[qRT-PCR]]></category>
		<category><![CDATA[tumour microenvironment]]></category>
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					<description><![CDATA[A new commentary in BMC Cancer warns that pan-cancer studies treating CFH as a single cancer biomarker have been measuring an aggregate of two distinct proteins, full-length factor H and the splice isoform FHL-1, which may play different roles in tumour biology.]]></description>
		
		
		
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