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	<title>familial anemia &#8211; BIOENGINEER.ORG</title>
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		<title>Germline STAT5B and somatic STAT3 variants converge in a family&#8217;s inherited anemia</title>
		<link>https://bioengineer.org/germline-stat5b-and-somatic-stat3-variants-converge-in-a-familys-inherited-anemia/</link>
		
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		<pubDate>Fri, 23 Oct 2026 23:03:10 +0000</pubDate>
				<category><![CDATA[Cancer]]></category>
		<category><![CDATA[anemia]]></category>
		<category><![CDATA[case report]]></category>
		<category><![CDATA[erythroid hypoplasia]]></category>
		<category><![CDATA[familial anemia]]></category>
		<category><![CDATA[Hematology]]></category>
		<category><![CDATA[next-generation sequencing]]></category>
		<category><![CDATA[sirolimus]]></category>
		<category><![CDATA[STAT3]]></category>
		<category><![CDATA[STAT5B]]></category>
		<category><![CDATA[T-cell large granular lymphocytic leukemia]]></category>
		<category><![CDATA[variant of uncertain significance]]></category>
		<category><![CDATA[whole-exome sequencing]]></category>
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					<description><![CDATA[A case report describes a family carrying an inherited STAT5B variant of uncertain significance in which anemia developed only in the two members who also acquired somatic STAT3 variants, and both improved on sirolimus treatment.]]></description>
		
		
		
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