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	<title>endothelial interaction &#8211; BIOENGINEER.ORG</title>
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		<title>Hidden Switch Lets Melanoma Cells Flip Into Metastasis Mode, Study Finds</title>
		<link>https://bioengineer.org/hidden-switch-lets-melanoma-cells-flip-into-metastasis-mode-study-finds/</link>
		
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		<pubDate>Thu, 15 Oct 2026 08:18:08 +0000</pubDate>
				<category><![CDATA[Cancer]]></category>
		<category><![CDATA[cell plasticity]]></category>
		<category><![CDATA[Circulating tumor cells]]></category>
		<category><![CDATA[endothelial interaction]]></category>
		<category><![CDATA[extracellular matrix]]></category>
		<category><![CDATA[integrin-mediated adhesion]]></category>
		<category><![CDATA[melanoma]]></category>
		<category><![CDATA[Metastasis]]></category>
		<category><![CDATA[MyD88]]></category>
		<category><![CDATA[NRAS-mutant melanoma]]></category>
		<category><![CDATA[patient-derived xenograft]]></category>
		<category><![CDATA[STAT3 Signaling]]></category>
		<category><![CDATA[tumor microenvironment]]></category>
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					<description><![CDATA[Researchers in Milan have identified MyD88 as a tumor cell-intrinsic switch that sustains a metastasis-competent, integrin-driven cell state in NRAS-mutant melanoma, impairing spread without affecting primary tumor growth when silenced.]]></description>
		
		
		
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