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	<title>ecDNA &#8211; BIOENGINEER.ORG</title>
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		<title>Cancer&#8217;s Rogue DNA Can Backfire, Trapping Oncogenes in Micronuclei and Slowing Tumors</title>
		<link>https://bioengineer.org/cancers-rogue-dna-can-backfire-trapping-oncogenes-in-micronuclei-and-slowing-tumors/</link>
		
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		<pubDate>Mon, 12 Oct 2026 12:41:43 +0000</pubDate>
				<category><![CDATA[Biology]]></category>
		<category><![CDATA[cancer biomarkers]]></category>
		<category><![CDATA[chromosomal instability]]></category>
		<category><![CDATA[ecDNA]]></category>
		<category><![CDATA[extrachromosomal DNA]]></category>
		<category><![CDATA[MDC1-CIP2A-TOPBP1]]></category>
		<category><![CDATA[micronuclei]]></category>
		<category><![CDATA[MYCN]]></category>
		<category><![CDATA[Nature Genetics]]></category>
		<category><![CDATA[Neuroblastoma]]></category>
		<category><![CDATA[oncogene amplification]]></category>
		<category><![CDATA[Replication stress]]></category>
		<category><![CDATA[tumor evolution]]></category>
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					<description><![CDATA[New research shows that damaged extrachromosomal DNA is trapped in transcriptionally silent micronuclei, impairing cancer cell fitness and predicting better survival in children with MYCN-amplified neuroblastoma.]]></description>
		
		
		
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