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	<title>drug discovery innovation &#8211; BIOENGINEER.ORG</title>
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		<title>Revolutionizing Drug Discovery with Customized 3D Molecular Design</title>
		<link>https://bioengineer.org/revolutionizing-drug-discovery-with-customized-3d-molecular-design/</link>
		
		<dc:creator><![CDATA[Bioengineer]]></dc:creator>
		<pubDate>Sat, 04 Oct 2025 12:52:34 +0000</pubDate>
				<category><![CDATA[Technology]]></category>
		<category><![CDATA[3D molecular modeling]]></category>
		<category><![CDATA[antibiotic resistance inhibitors]]></category>
		<category><![CDATA[drug discovery innovation]]></category>
		<category><![CDATA[machine learning in drug design]]></category>
		<category><![CDATA[pharmacophore-oriented molecular design]]></category>
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					<description><![CDATA[In the era of precision medicine and targeted therapies, molecular generation has emerged as a groundbreaking technology poised to transform the landscape of drug discovery. Traditional methods of molecular generation, primarily focused on ligand-based or structure-based approaches, have often failed to meet the demanding needs of real-world applications. These challenges underscore a significant gap in [&#8230;]]]></description>
		
		
		
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		<title>On-DNA C–H Functionalization Advances DNA-Encoded Libraries</title>
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		<dc:creator><![CDATA[Bioengineer]]></dc:creator>
		<pubDate>Mon, 16 Jun 2025 12:36:32 +0000</pubDate>
				<category><![CDATA[Chemistry]]></category>
		<category><![CDATA[combinatorial chemistry advancements]]></category>
		<category><![CDATA[DNA-encoded libraries (DELs)]]></category>
		<category><![CDATA[drug discovery innovation]]></category>
		<category><![CDATA[electron-rich arenes]]></category>
		<category><![CDATA[On-DNA C–H functionalization]]></category>
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					<description><![CDATA[In a groundbreaking advancement poised to reshape the landscape of drug discovery and chemical biology, researchers have unveiled innovative methodologies enabling the on-DNA C–H functionalization of electron-rich arenes to build DNA-encoded libraries (DELs) with unprecedented efficiency and diversity. This pioneering work, spearheaded by de Pedro Beato, Torkowski, Hartmann, and colleagues, introduces synthetic strategies that complement [&#8230;]]]></description>
		
		
		
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