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		<title>Chemists Crack the Recipe for Ring-Shaped Antibiotic Peptides with a Two-Job Molecular Handle</title>
		<link>https://bioengineer.org/chemists-crack-the-recipe-for-ring-shaped-antibiotic-peptides-with-a-two-job-molecular-handle/</link>
		
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		<pubDate>Tue, 13 Oct 2026 14:40:40 +0000</pubDate>
				<category><![CDATA[Chemistry]]></category>
		<category><![CDATA[antibiotics]]></category>
		<category><![CDATA[C–H activation]]></category>
		<category><![CDATA[density functional theory]]></category>
		<category><![CDATA[directing group]]></category>
		<category><![CDATA[macrocyclic peptides]]></category>
		<category><![CDATA[macrocyclization]]></category>
		<category><![CDATA[natural product synthesis]]></category>
		<category><![CDATA[RaS-RiPPs]]></category>
		<category><![CDATA[rhodium catalysis]]></category>
		<category><![CDATA[Streptococcus mutans]]></category>
		<category><![CDATA[tryglysin]]></category>
		<category><![CDATA[tryptophan crosslink]]></category>
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					<description><![CDATA[Princeton chemists have developed a rhodium-catalysed macrocyclization using a dual-functional directing group that enables general synthesis of tryptophan-crosslinked macrocyclic peptides, including pharmacophores of the antibiotic tryglysin.]]></description>
		
		
		
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