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	<title>diagnostic gene signature &#8211; BIOENGINEER.ORG</title>
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		<title>Smooth Muscle Cells Take Center Stage as Gene Study Reveals New Clues to Pulmonary Hypertension</title>
		<link>https://bioengineer.org/smooth-muscle-cells-take-center-stage-as-gene-study-reveals-new-clues-to-pulmonary-hypertension/</link>
		
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		<pubDate>Tue, 13 Oct 2026 19:34:04 +0000</pubDate>
				<category><![CDATA[Technology]]></category>
		<category><![CDATA[biomarkers]]></category>
		<category><![CDATA[bulk RNA-sequencing]]></category>
		<category><![CDATA[diagnostic gene signature]]></category>
		<category><![CDATA[hdWGCNA]]></category>
		<category><![CDATA[HIF-1alpha]]></category>
		<category><![CDATA[immune infiltration]]></category>
		<category><![CDATA[Machine Learning]]></category>
		<category><![CDATA[pulmonary hypertension]]></category>
		<category><![CDATA[single-cell RNA sequencing]]></category>
		<category><![CDATA[Smooth muscle cells]]></category>
		<category><![CDATA[TGF-beta signaling]]></category>
		<category><![CDATA[Vascular remodeling]]></category>
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					<description><![CDATA[By merging bulk and single-cell RNA sequencing with machine learning and lab experiments, researchers have identified smooth muscle cells as central communicators in pulmonary hypertension and pinpointed five genes, including MFGE8, SFRP2, S100A11, PCOLCE2, and C1R, that may serve as both diagnostic biomarkers and therapeutic targets.]]></description>
		
		
		
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