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		<title>Only a Small Fraction of Genetic Variants Ever Change Clinical Meaning, 13-Year Study Finds</title>
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		<pubDate>Fri, 23 Oct 2026 13:21:55 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[ACMG/AMP criteria]]></category>
		<category><![CDATA[cancer genes]]></category>
		<category><![CDATA[ClinVar]]></category>
		<category><![CDATA[database schema evolution]]></category>
		<category><![CDATA[ExAC]]></category>
		<category><![CDATA[Genetic Testing]]></category>
		<category><![CDATA[genomic medicine]]></category>
		<category><![CDATA[gnomAD]]></category>
		<category><![CDATA[Mendelian disease]]></category>
		<category><![CDATA[pathogenicity]]></category>
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					<description><![CDATA[A 13-year analysis of 3.68 million ClinVar variants found that only 0.68 percent ever crossed the clinically actionable boundary between pathogenic and benign classifications, with reclassification rates highest in cancer genes and common Mendelian diseases.]]></description>
		
		
		
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