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	<title>Cullin-RING ligase &#8211; BIOENGINEER.ORG</title>
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	<title>Cullin-RING ligase &#8211; BIOENGINEER.ORG</title>
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		<title>Scientists Discover a Molecular Switch That Drives T-Cell Exhaustion in Cancer Immunotherapy</title>
		<link>https://bioengineer.org/scientists-discover-a-molecular-switch-that-drives-t-cell-exhaustion-in-cancer-immunotherapy/</link>
		
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		<pubDate>Fri, 16 Oct 2026 20:17:04 +0000</pubDate>
				<category><![CDATA[Cancer]]></category>
		<category><![CDATA[adoptive cell therapy]]></category>
		<category><![CDATA[Cancer Immunology Research]]></category>
		<category><![CDATA[Cancer immunotherapy]]></category>
		<category><![CDATA[CAR-T cell therapy]]></category>
		<category><![CDATA[CRISPR screen]]></category>
		<category><![CDATA[CRL5]]></category>
		<category><![CDATA[Cullin-RING ligase]]></category>
		<category><![CDATA[melanoma]]></category>
		<category><![CDATA[MLN4924]]></category>
		<category><![CDATA[solid tumors]]></category>
		<category><![CDATA[T cell exhaustion]]></category>
		<category><![CDATA[UCLA]]></category>
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					<description><![CDATA[UCLA researchers used a genome-wide CRISPR screen to identify the Cullin-5 RING E3 ligase complex as a key driver of T-cell exhaustion, and blocking this pathway helped engineered immune cells stay active longer and fight solid tumors more effectively in preclinical models.]]></description>
		
		
		
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