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	<title>CRISPR Screens &#8211; BIOENGINEER.ORG</title>
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		<title>Bidirectional CRISPR Maps GLIS3 Fibrosis Circuit</title>
		<link>https://bioengineer.org/bidirectional-crispr-maps-glis3-fibrosis-circuit/</link>
		
		<dc:creator><![CDATA[Bioengineer]]></dc:creator>
		<pubDate>Thu, 08 Jan 2026 09:13:25 +0000</pubDate>
				<category><![CDATA[Technology]]></category>
		<category><![CDATA[Bidirectional CRISPR screens]]></category>
		<category><![CDATA[CRISPR Screens]]></category>
		<category><![CDATA[Fibrosis]]></category>
		<category><![CDATA[Fibrosis mechanisms]]></category>
		<category><![CDATA[GLIS3]]></category>
		<category><![CDATA[İçeriğe uygun 5 etiket: **GLIS3 transcription factor]]></category>
		<category><![CDATA[inflammatory bowel disease]]></category>
		<category><![CDATA[transcriptional regulation]]></category>
		<category><![CDATA[Transcriptional regulation** **Kısa açıklama:** 1. **GLIS3 transcription factor:** Makalenin temel odağı GLIS3'ün rolünü araştırması. 2. **Fibrosis mechanisms:** GLIS3'ün düzenlediği fib]]></category>
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					<description><![CDATA[A groundbreaking study reveals the pivotal role of the transcription factor GLIS3 in orchestrating a fibrotic cell circuit linked to inflammatory and fibrotic tissue remodeling. Employing state-of-the-art bidirectional CRISPR screens combined with RNA sequencing and chromatin immunoprecipitation assays, researchers have delineated a GLIS3-dependent program governing the behavior of inflammatory activated fibroblasts (IAFs), cells crucial to [&#8230;]]]></description>
		
		
		
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		<title>Epigenetic Drivers of Cardiac Fibrosis Uncovered</title>
		<link>https://bioengineer.org/epigenetic-drivers-of-cardiac-fibrosis-uncovered/</link>
		
		<dc:creator><![CDATA[Bioengineer]]></dc:creator>
		<pubDate>Wed, 26 Nov 2025 11:34:30 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[CRISPR Screens]]></category>
		<category><![CDATA[epigenetic regulation]]></category>
		<category><![CDATA[Fibroblast Activation]]></category>
		<category><![CDATA[İşte 5 adet uygun ve özlü etiket: **Cardiac Fibrosis]]></category>
		<category><![CDATA[Single-Cell Analysis** * **Cardiac Fibrosis:** Makalenin ana konusu. * **Epigenetic Regulation:** Keşfedilen temel mekanizma ve düzenleyiciler. * **CRISPR Screens:** Kullanılan anahtar metodolo]]></category>
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					<description><![CDATA[In a groundbreaking study published in Nature Communications in 2025, researchers led by Aguado-Alvaro, Garitano, Esser-Skala, and colleagues have unveiled critical insights into the epigenetic regulators driving fibrotic transformation in cardiac fibroblasts. This pioneering work leverages the power of both bulk and single-cell CRISPR screening technologies, offering an unprecedented molecular dissection of cardiac fibrosis—a pathological [&#8230;]]]></description>
		
		
		
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