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		<title>Lab Evolution&#8217;s Short Reach: E. coli Experiments Sample Less Than Half of Possible Amino Acid Swaps</title>
		<link>https://bioengineer.org/lab-evolutions-short-reach-e-coli-experiments-sample-less-than-half-of-possible-amino-acid-swaps/</link>
		
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		<pubDate>Sat, 17 Oct 2026 09:06:44 +0000</pubDate>
				<category><![CDATA[Biology]]></category>
		<category><![CDATA[adaptive laboratory evolution]]></category>
		<category><![CDATA[alleleome]]></category>
		<category><![CDATA[amino acid substitutions]]></category>
		<category><![CDATA[codon usage]]></category>
		<category><![CDATA[directed evolution]]></category>
		<category><![CDATA[Escherichia coli]]></category>
		<category><![CDATA[Genetic Code]]></category>
		<category><![CDATA[Metabolic engineering]]></category>
		<category><![CDATA[mutation bias]]></category>
		<category><![CDATA[thermotolerance]]></category>
		<category><![CDATA[transition mutations]]></category>
		<category><![CDATA[transversion mutations]]></category>
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					<description><![CDATA[A new analysis of roughly 25,000 amino acid substitutions from evolved E. coli shows that adaptive laboratory evolution samples less than half of the possible amino acid exchanges, constrained by the structure of the genetic code and mutation biases.]]></description>
		
		
		
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