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	<title>CIPA &#8211; BIOENGINEER.ORG</title>
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		<title>When Joint Destruction Hurts Nothing: Rare Pain Gene Mutation Masqueraded as Childhood Arthritis</title>
		<link>https://bioengineer.org/when-joint-destruction-hurts-nothing-rare-pain-gene-mutation-masqueraded-as-childhood-arthritis/</link>
		
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		<pubDate>Wed, 14 Oct 2026 22:32:12 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[anhidrosis]]></category>
		<category><![CDATA[CIPA]]></category>
		<category><![CDATA[congenital insensitivity to pain]]></category>
		<category><![CDATA[genetic diagnosis]]></category>
		<category><![CDATA[hereditary sensory and autonomic neuropathy]]></category>
		<category><![CDATA[juvenile idiopathic arthritis]]></category>
		<category><![CDATA[nerve growth factor]]></category>
		<category><![CDATA[neuropathic arthropathy]]></category>
		<category><![CDATA[NTRK1]]></category>
		<category><![CDATA[pediatric rheumatology]]></category>
		<category><![CDATA[TrkA]]></category>
		<category><![CDATA[whole-exome sequencing]]></category>
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					<description><![CDATA[Three Vietnamese children misdiagnosed with juvenile idiopathic arthritis were found to carry the same NTRK1 mutation causing congenital insensitivity to pain, with painlessness amid severe joint destruction serving as the key diagnostic clue.]]></description>
		
		
		
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