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	<title>chronic viral infection &#8211; BIOENGINEER.ORG</title>
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		<title>Gene brake ZMYND8 drives T-cell exhaustion and blocking it may strengthen immunotherapy</title>
		<link>https://bioengineer.org/gene-brake-zmynd8-drives-t-cell-exhaustion-and-blocking-it-may-strengthen-immunotherapy/</link>
		
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		<pubDate>Mon, 19 Oct 2026 08:53:45 +0000</pubDate>
				<category><![CDATA[Cancer]]></category>
		<category><![CDATA[CD8-positive T cells]]></category>
		<category><![CDATA[checkpoint blockade]]></category>
		<category><![CDATA[chronic viral infection]]></category>
		<category><![CDATA[CRISPR screening]]></category>
		<category><![CDATA[immunotherapy]]></category>
		<category><![CDATA[Interleukin 2]]></category>
		<category><![CDATA[Nature]]></category>
		<category><![CDATA[p300]]></category>
		<category><![CDATA[solid tumors]]></category>
		<category><![CDATA[St. Jude Children’s Research Hospital]]></category>
		<category><![CDATA[T cell exhaustion]]></category>
		<category><![CDATA[ZMYND8]]></category>
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					<description><![CDATA[St. Jude scientists found that deleting the gene ZMYND8 relieves CD8-positive T-cell exhaustion and synergizes with immunotherapy to improve anti-tumor and anti-viral responses in mice.]]></description>
		
		
		
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