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	<title>chemical biology &#8211; BIOENGINEER.ORG</title>
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		<title>Cancer Drug in Clinical Trials May Work Through an Entirely Different Target Than Assumed</title>
		<link>https://bioengineer.org/cancer-drug-in-clinical-trials-may-work-through-an-entirely-different-target-than-assumed/</link>
		
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		<pubDate>Tue, 06 Oct 2026 11:30:38 +0000</pubDate>
				<category><![CDATA[Cancer]]></category>
		<category><![CDATA[cancer drug development]]></category>
		<category><![CDATA[chemical biology]]></category>
		<category><![CDATA[Clinical Trials]]></category>
		<category><![CDATA[DHODH]]></category>
		<category><![CDATA[drug mechanism]]></category>
		<category><![CDATA[Glioblastoma]]></category>
		<category><![CDATA[KDM4]]></category>
		<category><![CDATA[Nature Chemical Biology]]></category>
		<category><![CDATA[QC6352]]></category>
		<category><![CDATA[targeted therapy]]></category>
		<category><![CDATA[University of Sydney]]></category>
		<category><![CDATA[zavondemstat]]></category>
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					<description><![CDATA[A new study finds the experimental cancer drug zavondemstat and the research compound QC6352 act mainly by blocking the enzyme DHODH rather than their intended KDM4 target, raising concerns about clinical trials and years of published research.]]></description>
		
		
		
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