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		<title>Engineered Flavonoid Cousins of Fisetin Clear Senescent Cells and Boost Healthspan in Mice</title>
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		<pubDate>Wed, 07 Oct 2026 13:34:10 +0000</pubDate>
				<category><![CDATA[Biology]]></category>
		<category><![CDATA[Aging]]></category>
		<category><![CDATA[Aging Cell]]></category>
		<category><![CDATA[CDK2]]></category>
		<category><![CDATA[Cellular Senescence]]></category>
		<category><![CDATA[fisetin]]></category>
		<category><![CDATA[flavonoids]]></category>
		<category><![CDATA[healthspan]]></category>
		<category><![CDATA[PARP1]]></category>
		<category><![CDATA[phenotypic drug discovery]]></category>
		<category><![CDATA[preclinical]]></category>
		<category><![CDATA[SASP]]></category>
		<category><![CDATA[senolytics]]></category>
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					<description><![CDATA[Researchers engineered two fisetin-derived flavonoid analogs that kill senescent cells up to 27 times more potently than fisetin and reduce senescence markers in aged mice by targeting PARP1 and CDK2.]]></description>
		
		
		
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