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	<title>C-terminal tail &#8211; BIOENGINEER.ORG</title>
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		<title>Molecular Brake Found That Keeps Lipid-Scrambling Protein TMEM63B Switched Off</title>
		<link>https://bioengineer.org/molecular-brake-found-that-keeps-lipid-scrambling-protein-tmem63b-switched-off/</link>
		
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		<pubDate>Sun, 11 Oct 2026 16:57:45 +0000</pubDate>
				<category><![CDATA[Biology]]></category>
		<category><![CDATA[autoinhibition]]></category>
		<category><![CDATA[C-terminal tail]]></category>
		<category><![CDATA[conformational regulation]]></category>
		<category><![CDATA[Journal of Biological Chemistry]]></category>
		<category><![CDATA[Leu776]]></category>
		<category><![CDATA[lipid scramblase]]></category>
		<category><![CDATA[mechanosensitive protein]]></category>
		<category><![CDATA[membrane asymmetry]]></category>
		<category><![CDATA[neurodegenerative disease]]></category>
		<category><![CDATA[phosphatidylserine]]></category>
		<category><![CDATA[plasma membrane]]></category>
		<category><![CDATA[TMEM63B]]></category>
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					<description><![CDATA[Researchers at Institute of Science Tokyo show that the C-terminal tail of TMEM63B, particularly the Leu776 residue, acts as an autoinhibitory molecular brake that keeps the mechanosensitive lipid scramblase inactive until membrane changes release it.]]></description>
		
		
		
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