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	<title>birth cohort effects &#8211; BIOENGINEER.ORG</title>
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		<title>Birth Cohorts and Bias Distort How Genes Shape Traits Across Age</title>
		<link>https://bioengineer.org/birth-cohorts-and-bias-distort-how-genes-shape-traits-across-age/</link>
		
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		<pubDate>Thu, 08 Oct 2026 18:22:28 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[age-varying genetic effects]]></category>
		<category><![CDATA[birth cohort effects]]></category>
		<category><![CDATA[complex traits]]></category>
		<category><![CDATA[cross-sectional design]]></category>
		<category><![CDATA[gene-by-age interaction]]></category>
		<category><![CDATA[Genetic epidemiology]]></category>
		<category><![CDATA[Genome-wide association study]]></category>
		<category><![CDATA[longitudinal analysis]]></category>
		<category><![CDATA[Mendelian randomization]]></category>
		<category><![CDATA[participation bias]]></category>
		<category><![CDATA[polygenic scores]]></category>
		<category><![CDATA[UK Biobank]]></category>
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					<description><![CDATA[A large UK Biobank analysis shows that cross-sectional and longitudinal studies yield directionally consistent but systematically different estimates of age-varying genetic effects, driven mainly by birth cohort confounding and participation bias.]]></description>
		
		
		
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