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		<title>Why Promising Immune Biomarkers Collapse in the Clinic: New Framework Predicts Failure Before Validation</title>
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		<pubDate>Thu, 08 Oct 2026 06:37:38 +0000</pubDate>
				<category><![CDATA[Biology]]></category>
		<category><![CDATA[biomarker fragility]]></category>
		<category><![CDATA[biomarker translation]]></category>
		<category><![CDATA[BMC Bioinformatics]]></category>
		<category><![CDATA[bulk RNA-sequencing]]></category>
		<category><![CDATA[Cancer immunotherapy]]></category>
		<category><![CDATA[immune biomarkers]]></category>
		<category><![CDATA[immune checkpoint blockade]]></category>
		<category><![CDATA[phenotypic inflation]]></category>
		<category><![CDATA[single-cell RNA sequencing]]></category>
		<category><![CDATA[TCGA]]></category>
		<category><![CDATA[Transcriptomics]]></category>
		<category><![CDATA[tumor microenvironment]]></category>
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					<description><![CDATA[A new computational framework quantifies why immune biomarkers that perform brilliantly in discovery datasets so often fail in clinical validation, and shows how to predict those failures in advance.]]></description>
		
		
		
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