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	<title>Bidirectional CRISPR screens &#8211; BIOENGINEER.ORG</title>
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	<title>Bidirectional CRISPR screens &#8211; BIOENGINEER.ORG</title>
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		<title>Bidirectional CRISPR Maps GLIS3 Fibrosis Circuit</title>
		<link>https://bioengineer.org/bidirectional-crispr-maps-glis3-fibrosis-circuit/</link>
		
		<dc:creator><![CDATA[Bioengineer]]></dc:creator>
		<pubDate>Thu, 08 Jan 2026 09:13:25 +0000</pubDate>
				<category><![CDATA[Technology]]></category>
		<category><![CDATA[Bidirectional CRISPR screens]]></category>
		<category><![CDATA[CRISPR Screens]]></category>
		<category><![CDATA[Fibrosis]]></category>
		<category><![CDATA[Fibrosis mechanisms]]></category>
		<category><![CDATA[GLIS3]]></category>
		<category><![CDATA[İçeriğe uygun 5 etiket: **GLIS3 transcription factor]]></category>
		<category><![CDATA[inflammatory bowel disease]]></category>
		<category><![CDATA[transcriptional regulation]]></category>
		<category><![CDATA[Transcriptional regulation** **Kısa açıklama:** 1. **GLIS3 transcription factor:** Makalenin temel odağı GLIS3'ün rolünü araştırması. 2. **Fibrosis mechanisms:** GLIS3'ün düzenlediği fib]]></category>
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					<description><![CDATA[A groundbreaking study reveals the pivotal role of the transcription factor GLIS3 in orchestrating a fibrotic cell circuit linked to inflammatory and fibrotic tissue remodeling. Employing state-of-the-art bidirectional CRISPR screens combined with RNA sequencing and chromatin immunoprecipitation assays, researchers have delineated a GLIS3-dependent program governing the behavior of inflammatory activated fibroblasts (IAFs), cells crucial to [&#8230;]]]></description>
		
		
		
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