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	<title>beta-lactamase inhibitors &#8211; BIOENGINEER.ORG</title>
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		<title>Superbug With Multiple Carbapenemases Shows Genomic Diversity but New Drug Combinations Hold the Line</title>
		<link>https://bioengineer.org/superbug-with-multiple-carbapenemases-shows-genomic-diversity-but-new-drug-combinations-hold-the-line/</link>
		
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		<pubDate>Sun, 11 Oct 2026 13:02:46 +0000</pubDate>
				<category><![CDATA[Biology]]></category>
		<category><![CDATA[Antimicrobial Resistance]]></category>
		<category><![CDATA[aztreonam/avibactam]]></category>
		<category><![CDATA[beta-lactamase inhibitors]]></category>
		<category><![CDATA[bloodstream infections]]></category>
		<category><![CDATA[cefepime/zidebactam]]></category>
		<category><![CDATA[cefiderocol]]></category>
		<category><![CDATA[hospital surveillance]]></category>
		<category><![CDATA[Klebsiella pneumoniae]]></category>
		<category><![CDATA[metallo-beta-lactamase]]></category>
		<category><![CDATA[multi-carbapenemase]]></category>
		<category><![CDATA[plasmid-mediated resistance]]></category>
		<category><![CDATA[whole-genome sequencing]]></category>
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					<description><![CDATA[A two-year, 14-hospital Italian study found that multi-carbapenemase-producing Klebsiella pneumoniae isolates are genomically diverse and extensively resistant, yet aztreonam/avibactam and cefepime/zidebactam retained full in vitro activity while aztreonam-based combinations showed consistent synergy against metallo-beta-lactamase producers.]]></description>
		
		
		
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