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	<title>atom swap &#8211; BIOENGINEER.ORG</title>
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		<title>Chemists Swap Oxygen for Sulfur in Four-Membered Rings in a Single Step</title>
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		<pubDate>Mon, 12 Oct 2026 13:19:42 +0000</pubDate>
				<category><![CDATA[Chemistry]]></category>
		<category><![CDATA[atom swap]]></category>
		<category><![CDATA[DFT calculations]]></category>
		<category><![CDATA[drug discovery]]></category>
		<category><![CDATA[four-membered rings]]></category>
		<category><![CDATA[heterocycles]]></category>
		<category><![CDATA[Medicinal Chemistry]]></category>
		<category><![CDATA[organic synthesis]]></category>
		<category><![CDATA[oxetanes]]></category>
		<category><![CDATA[reaction mechanism]]></category>
		<category><![CDATA[Skeletal editing]]></category>
		<category><![CDATA[thietanes]]></category>
		<category><![CDATA[thiourea]]></category>
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					<description><![CDATA[Researchers report a one-step skeletal editing reaction that converts readily available oxetanes into thietanes using thiourea, enabling direct oxygen-to-sulfur atom swaps in drug-like molecules.]]></description>
		
		
		
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