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	<title>APDS &#8211; BIOENGINEER.ORG</title>
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		<title>Sirolimus and Antibody Replacement Fall Short of Proof in Rare Immune Syndrome Review</title>
		<link>https://bioengineer.org/sirolimus-and-antibody-replacement-fall-short-of-proof-in-rare-immune-syndrome-review/</link>
		
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		<pubDate>Mon, 26 Oct 2026 21:01:31 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[APDS]]></category>
		<category><![CDATA[case reports]]></category>
		<category><![CDATA[immunoglobulin replacement therapy]]></category>
		<category><![CDATA[inborn errors of immunity]]></category>
		<category><![CDATA[leniolisib]]></category>
		<category><![CDATA[lymphoproliferation]]></category>
		<category><![CDATA[mTOR inhibitor]]></category>
		<category><![CDATA[PI3K delta]]></category>
		<category><![CDATA[primary immunodeficiency]]></category>
		<category><![CDATA[rare disease]]></category>
		<category><![CDATA[sirolimus]]></category>
		<category><![CDATA[systematic review]]></category>
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					<description><![CDATA[A systematic review of 79 records found no prospective trials of sirolimus or immunoglobulin replacement therapy in APDS, with evidence dominated by low-quality case reports that cannot reliably quantify treatment benefit.]]></description>
		
		
		
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