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	<title>amyotrophic lateral sclerosis &#8211; BIOENGINEER.ORG</title>
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		<title>TDP-43 Loss Triggers Broad Polyadenylation Shifts in FTD/ALS</title>
		<link>https://bioengineer.org/tdp-43-loss-triggers-broad-polyadenylation-shifts-in-ftd-als/</link>
		
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		<pubDate>Tue, 21 Oct 2025 10:55:21 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[alternative polyadenylation]]></category>
		<category><![CDATA[amyotrophic lateral sclerosis]]></category>
		<category><![CDATA[frontotemporal dementia]]></category>
		<category><![CDATA[RNA processing abnormalities]]></category>
		<category><![CDATA[TDP-43]]></category>
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					<description><![CDATA[In a groundbreaking study published in Nature Neuroscience, researchers have unveiled that the nuclear depletion of the protein TDP-43 in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) is linked to widespread alterations in alternative polyadenylation (APA) across the genome. This revelation not only advances our understanding of the molecular pathology underpinning these devastating neurodegenerative [&#8230;]]]></description>
		
		
		
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