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		<title>Brain&#8217;s Kappa-Opioid Switch: New Map Reveals How Dynorphin Circuits Drive Depression and Anxiety</title>
		<link>https://bioengineer.org/brains-kappa-opioid-switch-new-map-reveals-how-dynorphin-circuits-drive-depression-and-anxiety/</link>
		
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		<pubDate>Thu, 08 Oct 2026 20:38:06 +0000</pubDate>
				<category><![CDATA[Biology]]></category>
		<category><![CDATA[amygdala]]></category>
		<category><![CDATA[Anxiety]]></category>
		<category><![CDATA[BDNF]]></category>
		<category><![CDATA[Depression]]></category>
		<category><![CDATA[dynorphin]]></category>
		<category><![CDATA[Hippocampus]]></category>
		<category><![CDATA[kappa-opioid receptor]]></category>
		<category><![CDATA[KOR antagonists]]></category>
		<category><![CDATA[neural circuits]]></category>
		<category><![CDATA[nucleus accumbens]]></category>
		<category><![CDATA[prefrontal cortex]]></category>
		<category><![CDATA[ventral tegmental area]]></category>
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					<description><![CDATA[A new review maps how the kappa-opioid receptor/dynorphin system acts as a circuit-specific switch in the brain's fear and reward pathways, offering a mechanistic foundation for kappa-antagonist antidepressants now in clinical trials.]]></description>
		
		
		
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