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	<title>alternative translation initiation &#8211; BIOENGINEER.ORG</title>
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		<title>Hidden p53 Variant Δ246p53 Emerges as a DNA Damage Sentinel Driving Cellular Senescence</title>
		<link>https://bioengineer.org/hidden-p53-variant-%ce%b4246p53-emerges-as-a-dna-damage-sentinel-driving-cellular-senescence/</link>
		
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		<pubDate>Fri, 09 Oct 2026 21:48:04 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[Aging]]></category>
		<category><![CDATA[alternative translation initiation]]></category>
		<category><![CDATA[cancer biology]]></category>
		<category><![CDATA[Cellular Senescence]]></category>
		<category><![CDATA[DNA damage]]></category>
		<category><![CDATA[p21]]></category>
		<category><![CDATA[p53]]></category>
		<category><![CDATA[protein isoform]]></category>
		<category><![CDATA[TP53]]></category>
		<category><![CDATA[tumor suppression]]></category>
		<category><![CDATA[Δ246p53]]></category>
		<category><![CDATA[ΔNp63]]></category>
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					<description><![CDATA[Researchers have discovered Δ246p53, a conserved 18-kilodalton p53 isoform translated from codon 246 that responds to DNA damage and enhances p53 family-driven senescence through interactions with full-length p53 and ΔNp63.]]></description>
		
		
		
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