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		<title>Lactate Fuels a Deadly Feedback Loop That Drives Gut Damage in Ulcerative Colitis</title>
		<link>https://bioengineer.org/lactate-fuels-a-deadly-feedback-loop-that-drives-gut-damage-in-ulcerative-colitis/</link>
		
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		<pubDate>Tue, 06 Oct 2026 17:09:45 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[ACSL4]]></category>
		<category><![CDATA[ACSS2]]></category>
		<category><![CDATA[ferroptosis]]></category>
		<category><![CDATA[H3K18la]]></category>
		<category><![CDATA[Histone lactylation]]></category>
		<category><![CDATA[HK2]]></category>
		<category><![CDATA[inflammatory bowel disease]]></category>
		<category><![CDATA[intestinal epithelial cells]]></category>
		<category><![CDATA[lactate]]></category>
		<category><![CDATA[lipid nanoparticles]]></category>
		<category><![CDATA[metabolic feedback loop]]></category>
		<category><![CDATA[ulcerative colitis]]></category>
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					<description><![CDATA[A new study in Genome Medicine reveals that lactate produced by inflamed gut cells fuels an ACSS2-driven histone lactylation feedback loop that amplifies ferroptotic epithelial injury in ulcerative colitis, and shows that targeted nanoparticle delivery of ACSS2 siRNA can break the loop and reverse colitis in mice.]]></description>
		
		
		
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