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Below please find a summary of an editorial that will be published online at www.Annals.org. The summary is not intended to substitute for the full article as a source of information.
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New CDC nPEP Guidelines should become ‘part of general medical practice’
Abstract: https://www.acpjournals.org/doi/10.7326/ANNALS-25-01885
A new commentary published in Annals of Internal Medicine from Roy Gulick, MD, Chief, Division of Infectious Diseases and Professor of Medicine at Weill Cornell Medicine, highlights what’s new in the updated CDC HIV Non-Occupational Post Exposure Prophylaxis (nPEP) Guidelines. According to Dr. Gulick, the streamlined nPEP guidelines should be part of general medical practice, as incorporating them will reduce new HIV infections and improve public health.
Last updated in 2016, the updated CDC nPEP Guidelines aptly incorporate a number of innovations and developments in the field since their last iteration. nPEP remains recommended for anyone with substantial risk of exposure through sexual contact or needle use, and the new guidelines outline additional relevant factors to use when assessing the exposure. These include the HIV RNA level of the source and whether the person exposed was taking PrEP. The updated guidelines stress the importance of taking nPEP as soon as possible, ideally within 24 hours (in contrast to the 2016 guidelines of 72 hours). The newly preferred nPEP regimens include three drugs: an HIV integrase inhibitor, either bictegravir or dolutegravir, together with 2 nucleoside analogue reverse transcriptase inhibitors (NRTIs, tenofovir [alafenamide or disoproxil fumarate] with emtricitabine or lamivudine). A person who is a candidate for nPEP should be tested for HIV by either a rapid test, a combination antigen-antibody test, or both. The new recommendations recommend an HIV RNA test for those who took injectable long-acting PrEP.
Finally, an important part of the new guidelines includes the CDC Guidance section, which offers suggestions and considerations for providers when implementing nPEP. Notably, the strategy of “PEP to PrEP” is outlined as an option for those who have an ongoing risk of contracting HIV sexually or through injection.
Media contacts: For a PDF, please contact Angela Collom at [email protected]. For an interview with author Roy M. Gulick, M.D. please email Krystle Lopez at [email protected].
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Journal
Annals of Internal Medicine
DOI
10.7326/ANNALS-25-01885
Method of Research
News article
Subject of Research
People
Article Title
PEP Rally: Updated CDC HIV Non-Occupational Post Exposure Prophylaxis (PEP) Guidelines
Article Publication Date
6-May-2025
Media Contact
Angela Collom
American College of Physicians
Office: 215-351-2653
Journal
Annals of Internal Medicine
DOI
10.7326/ANNALS-25-01885
Journal
Annals of Internal Medicine
DOI
10.7326/ANNALS-25-01885
Method of Research
News article
Subject of Research
People
Article Title
PEP Rally: Updated CDC HIV Non-Occupational Post Exposure Prophylaxis (PEP) Guidelines
Article Publication Date
6-May-2025
Keywords
/Life sciences/Microbiology/Microorganisms/Viruses/Human immunodeficiency virus
/Health and medicine/Clinical medicine/Medical treatments/Drug therapy
bu içeriği en az 2000 kelime olacak şekilde ve alt başlıklar ve madde içermiyecek şekilde ünlü bir science magazine için İngilizce olarak yeniden yaz. Teknik açıklamalar içersin ve viral olacak şekilde İngilizce yaz. Haber dışında başka bir şey içermesin. Haber içerisinde en az 12 paragraf ve her bir paragrafta da en az 50 kelime olsun. Cevapta sadece haber olsun. Ayrıca haberi yazdıktan sonra içerikten yararlanarak aşağıdaki başlıkların bilgisi var ise haberin altında doldur. Eğer yoksa bilgisi ilgili kısmı yazma.:
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Keywords
Tags: assessing HIV exposure risk factorsCDC nPEP Guidelinesgeneral medical practice integrationhealthcare practices for HIV preventionHIV Non-Occupational Post Exposure Prophylaxisimportance of timely nPEP administrationinfectious diseases managementinnovations in HIV treatmentpublic health improvement strategiesreducing new HIV infectionsRoy Gulick commentaryupdated HIV prevention guidelines
