Published today in Nature, scientists in the lab of Taekjip Ha at Boston Children’s Hospital have discovered a surprising feature hidden in the tiny building blocks of our genome known as the nucleosomes. Their findings suggest that these molecules, which look like little ‘tuna cans’, come pre-programmed with a physical code dictating their role in genome architecture, instructing the genome to assemble into unique 3D structures to suit the need for functions of different bodily organs. This insight could have broad implications, offering new clues into the maintenance of cellular function and the development of diseases such as autoimmunity and cancer.
Journal
Nature
DOI
10.1038/s41586-025-08971-7
Article Title
Native nucleosomes intrinsically encode genome organization principles
Article Publication Date
7-May-2025
Media Contact
Joelle Zaslow
Boston Children’s Hospital
Journal
Nature
DOI
10.1038/s41586-025-08971-7
Journal
Nature
DOI
10.1038/s41586-025-08971-7
Article Title
Native nucleosomes intrinsically encode genome organization principles
Article Publication Date
7-May-2025
Keywords
/Life sciences/Cell biology/Cellular physiology/Cell morphology/Cell structure/Organelles/Cell nuclei/Chromatin/Nucleosomes
/Life sciences/Genetics/Genomics/Genome organization
/Life sciences/Genetics/Genomics
/Life sciences/Genetics/Molecular genetics/Gene expression
bu içeriği en az 2000 kelime olacak şekilde ve alt başlıklar ve madde içermiyecek şekilde ünlü bir science magazine için İngilizce olarak yeniden yaz. Teknik açıklamalar içersin ve viral olacak şekilde İngilizce yaz. Haber dışında başka bir şey içermesin. Haber içerisinde en az 12 paragraf ve her bir paragrafta da en az 50 kelime olsun. Cevapta sadece haber olsun. Ayrıca haberi yazdıktan sonra içerikten yararlanarak aşağıdaki başlıkların bilgisi var ise haberin altında doldur. Eğer yoksa bilgisi ilgili kısmı yazma.:
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Keywords
Tags: 3D structures in biologyBoston Children’s Hospital discoveriescancer development insightscellular function maintenanceepigenetics and genome architecturegene expression and structuregenome architecture principlesimplications for autoimmunitymolecular biology breakthroughsnucleosome genome organizationphysical code in nucleosomesTaekjip Ha research findings
