About The Study: In this phase 3 study, mRNA-1083, an investigational, multicomponent vaccine against seasonal influenza and SARS-CoV-2, met noninferiority criteria and induced higher immune responses than recommended standard care influenza (standard and high dose) and COVID-19 vaccines against all 4 influenza strains (among those ages 50-64), the 3 clinically relevant influenza strains (among those age 65 and older), and SARS-CoV-2 (all ages), with an acceptable tolerability and safety profile.
Corresponding Author: To contact the corresponding author, Amanda K. Rudman Spergel, MD, email [email protected].
To access the embargoed study: Visit our For The Media website at this link
(doi:10.1001/jama.2025.5646)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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JAMA
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JAMA Network Media Relations
JAMA Network
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JAMA
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JAMA
Keywords
/Health and medicine/Clinical medicine/Preventive medicine/Vaccination
/Health and medicine/Clinical medicine/Preventive medicine/Vaccination/COVID 19 vaccines
/Health and medicine/Diseases and disorders/Infectious diseases/Influenza
/Social sciences/Demography/Age groups/Adults/Older adults
/Social sciences/Demography/Age groups
/Physical sciences/Earth sciences/Climatology/Climate variability/Seasonal changes
/Life sciences/Microbiology/Microorganisms/Viruses/Coronavirus/SARS CoV 2
/Life sciences/Immunology/Immune response/Immunogenicity
/Life sciences/Genetics/Molecular genetics/Genetic material/RNA
bu içeriği en az 2000 kelime olacak şekilde ve alt başlıklar ve madde içermiyecek şekilde ünlü bir science magazine için İngilizce olarak yeniden yaz. Teknik açıklamalar içersin ve viral olacak şekilde İngilizce yaz. Haber dışında başka bir şey içermesin. Haber içerisinde en az 12 paragraf ve her bir paragrafta da en az 50 kelime olsun. Cevapta sadece haber olsun. Ayrıca haberi yazdıktan sonra içerikten yararlanarak aşağıdaki başlıkların bilgisi var ise haberin altında doldur. Eğer yoksa bilgisi ilgili kısmı yazma.:
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Tags: clinical relevance of vaccine trialscomparative vaccine efficacy for influenzaimmune response in adults over 50immunogenicity of multicomponent vaccinesinfluenza and COVID-19 vaccine safetymRNA-1083 vaccine studymulticomponent vaccines for adultsolder adults vaccine responsephase 3 vaccine trial resultsSARS-CoV-2 immunity in seniorsseasonal influenza vaccine effectivenessvaccine safety profiles for older populations
