Because life expectancy for individuals with Down syndrome has increased dramatically, investigators assessed the risk of age-related cardiovascular diseases in this population. As reported in the Journal of Internal Medicine, the researchers found increased risks of various cardiovascular diseases compared with the general population.
In the study, 5,155 individuals with Down syndrome born in Sweden in 1946–2000 were compared with other Swedish individuals matched by sex, birthyear, and county of birth.
Down syndrome was associated with 4.41-times higher risk of ischemic stroke and a 5.14-times higher risk of hemorrhagic stroke. (Ischemic strokes occur due to blocked blood flow to the brain, whereas hemorrhagic strokes are caused by bleeding in or around the brain.) The overall risk of heart attack was similar in people with Down syndrome and other individuals but was increased in young people with Down syndrome.
“Our results show that individuals with Down syndrome are at increased risk of some age-related cardiovascular outcomes, and indicate, in line with results from previous studies, that their cardiovascular risk factor profile differs from the general population. This could have future implications for the surveillance and treatment of individuals with Downs syndrome,” said corresponding author Annie Pedersen, PhD, of the University of Gothenburg, in Sweden.
URL upon publication:
Additional Information
NOTE: The information contained in this release is protected by copyright. Please include journal attribution in all coverage. For more information or to obtain a PDF of any study, please contact: Sara Henning-Stout, [email protected].
About the Journal
Journal of Internal Medicine is a peer-reviewed scientific journal that publishes original clinical work from bench to bedside covering a broad field of its subspecialties. JIM features original articles, reviews and clinical updates.
About Wiley
Wiley is one of the world’s largest publishers and a trusted leader in research and learning. Our industry-leading content, services, platforms, and knowledge networks are tailored to meet the evolving needs of our customers and partners, including researchers, students, instructors, professionals, institutions, and corporations. We empower knowledge-seekers to transform today’s biggest obstacles into tomorrow’s brightest opportunities. For more than two centuries, Wiley has been delivering on its timeless mission to unlock human potential. Visit us at Wiley.com. Follow us on Facebook, X, LinkedIn and Instagram.
Journal
Journal of Internal Medicine
DOI
10.1111/joim.20093
Article Title
Age-related cardiovascular disease in Down syndrome: A population-based matched cohort study
Article Publication Date
7-May-2025
Media Contact
Sara Henning-Stout
Wiley
Office: 9714294230
Journal
Journal of Internal Medicine
DOI
10.1111/joim.20093
Journal
Journal of Internal Medicine
DOI
10.1111/joim.20093
Article Title
Age-related cardiovascular disease in Down syndrome: A population-based matched cohort study
Article Publication Date
7-May-2025
Keywords
/Health and medicine/Diseases and disorders/Genetic disorders/Down syndrome
/Health and medicine/Diseases and disorders/Vascular diseases/Cardiovascular disorders/Cardiovascular disease
/Social sciences/Demography/Population/Subpopulations/Aging populations
/Health and medicine/Diseases and disorders/Vascular diseases/Cardiovascular disorders/Heart disease
bu içeriği en az 2000 kelime olacak şekilde ve alt başlıklar ve madde içermiyecek şekilde ünlü bir science magazine için İngilizce olarak yeniden yaz. Teknik açıklamalar içersin ve viral olacak şekilde İngilizce yaz. Haber dışında başka bir şey içermesin. Haber içerisinde en az 12 paragraf ve her bir paragrafta da en az 50 kelime olsun. Cevapta sadece haber olsun. Ayrıca haberi yazdıktan sonra içerikten yararlanarak aşağıdaki başlıkların bilgisi var ise haberin altında doldur. Eğer yoksa bilgisi ilgili kısmı yazma.:
Subject of Research:
Article Title:
News Publication Date:
Web References:
References:
Image Credits:
Keywords
Tags: age-related health risks in Down syndromeaging and Down syndromecardiovascular health in individuals with Down syndromecardiovascular risk factors in Down syndromeDown syndrome and cardiovascular diseaseheart attack risk in Down syndromehemorrhagic stroke risk in Down syndromeischemic stroke risk in Down syndromelife expectancy and Down syndromeresearch on Down syndrome and cardiovascular outcomessurveillance of Down syndrome healthtreatment implications for Down syndrome