• HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
Sunday, March 7, 2021
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Cancer

Oncotarget: Heterogeneity of CEACAM5 in breast cancer

Bioengineer by Bioengineer
November 3, 2020
in Cancer
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

Oncotarget recently published ‘Heterogeneity of CEACAM5 in breast cancer’ which reported that Here, we examined a repository of 110 cryopreserved primary breast carcinomas by immunohistochemistry to assess the distribution of CEACAM5 in tumor subtypes

IMAGE

Credit: Correspondence to – René Villadsen – [email protected]

Oncotarget recently published “Heterogeneity of CEACAM5 in breast cancer” which reported that Here, we examined a repository of 110 cryopreserved primary breast carcinomas by immunohistochemistry to assess the distribution of CEACAM5 in tumor subtypes.

Assessing sample sets of paired primary breast cancers and corresponding lymph node lesions from a total of 59 patients revealed a high correlation between primary tumor and lymph node with regard to CEACAM5-status.

When examining the consequence of expression of CEACAM5 in breast cancer cell lines in culture assays we found that CEACAM5-expressing cells were less invasive.

In survival analysis, using cohort studies of breast cancer, the expression of CEACAM5 predicted different clinical outcomes depending on molecular subtypes.

Altogether, our analysis suggests that CEACAM5 plays a context-dependent role in breast cancer that warrants further investigation.

Dr. René Villadsen from The University of Copenhagen said, “The carcinoembryonic antigen family (CEA) consists of a subgroup of 12 members of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), and several of these are reportedly overexpressed in various cancers.“

Early work suggested that CEACAM5 was also often overexpressed in breast cancer.

Since then several immunobased assays have been implemented to examine the role of CEACAM5 as a clinically relevant marker in breast cancer.

While some studies have demonstrated that increased serum levels in preoperative breast cancer patients do correlate to a worse outcome others have Immunophenotypic.

A summary of the observed results are available in Table 1. Overall, the available data do not provide a consensus on the role of CEACAM5 in breast cancer.

Here, we assess CEACAM5 expression in breast cancer subtypes by immunohistochemistry, and compare the expression pattern in primary tumors to corresponding lymph node metastases.

The Villadsen Research Team concluded in their Oncotarget Research Paper, “the findings in this study may help improve the understanding of the biological effect of CEACAM5-expression in breast cancer.“

###

Sign up for free Altmetric alerts about this article

DOI – https://doi.org/10.18632/oncotarget.27778

Full text – https://www.oncotarget.com/article/27778/text/

Correspondence to – René Villadsen – [email protected]

Keywords –
CEACAM5,
CEA,
immunohistochemistry,
breast cancer,
invasion

About Oncotarget

Oncotarget is a weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology.

To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with:

SoundCloud – https://soundcloud.com/oncotarget
Facebook – https://www.facebook.com/Oncotarget/
Twitter – https://twitter.com/oncotarget
LinkedIn – https://www.linkedin.com/company/oncotarget
Pinterest – https://www.pinterest.com/oncotarget/
Reddit – https://www.reddit.com/user/Oncotarget/

Oncotarget is published by Impact Journals, LLC please visit http://www.ImpactJournals.com or connect with @ImpactJrnls

Media Contact

[email protected]
18009220957×105

Media Contact
RYAN JAMES JESSUP
[email protected]

Original Source

https://www.oncotarget.com/news/pr/heterogeneity-of-ceacam5-in-breast-cancer/

Related Journal Article

http://dx.doi.org/10.18632/oncotarget.27778

Tags: BiologyBreast CancerBusiness/EconomicscancerCarcinogensEducationMedicine/HealthPolicy/EthicsProstate Cancer
Share12Tweet8Share2ShareShareShare2

Related Posts

IMAGE

Engineered ‘off the shelf’ stem cells target breast cancer that metastasizes to the brain

March 5, 2021
IMAGE

Cancer ‘guardian’ breaks bad with one switch

March 4, 2021

Engineered safety switch curbs severe side effects of CAR-T immunotherapy

March 4, 2021

HKBU develops dual-targeting drug for EBV-related cancers

March 2, 2021

Leave a Reply Cancel reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.

POPULAR NEWS

  • IMAGE

    Terahertz accelerates beyond 5G towards 6G

    668 shares
    Share 267 Tweet 167
  • People living with HIV face premature heart disease and barriers to care

    84 shares
    Share 34 Tweet 21
  • Global analysis suggests COVID-19 is seasonal

    39 shares
    Share 16 Tweet 10
  • HIV: an innovative therapeutic breakthrough to optimize the immune system

    36 shares
    Share 14 Tweet 9

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Tags

Climate ChangecancerMaterialsCell BiologyChemistry/Physics/Materials SciencesBiologyTechnology/Engineering/Computer ScienceInfectious/Emerging DiseasesPublic HealthEcology/EnvironmentMedicine/HealthGenetics

Recent Posts

  • “Magic sand” might help us understand the physics of granular matter
  • Study reveals how egg cells get so big
  • Survey identifies factors in reducing clinical research coordinator turnover
  • New ‘split-drive’ system puts scientists in the (gene) driver seat
  • Contact Us

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

Welcome Back!

Login to your account below

Forgotten Password?

Create New Account!

Fill the forms below to register

All fields are required. Log In

Retrieve your password

Please enter your username or email address to reset your password.

Log In