• HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
Monday, May 23, 2022
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News

Dr. Zhiqiang Lin awarded NIH Grant to examine the cardiac innate immune response

Bioengineer by Bioengineer
March 10, 2022
in Science News
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

UTICA, NY — In the United States, an individual will experience a heart attack every 40 seconds (CDC.gov). As a result of this damage, the body mounts an inflammatory response in an attempt to heal the injury. However, while initially protective, over time, excessive inflammation can actually cause even more damage to the tissue, contributing to heart muscle cell death and to an overall weakening of the heart itself. Dr. Zhiqiang Lin, Assistant Professor at the Masonic Medical Research Institute (MMRI), along with his colleagues, are actively investigating heart disease and inflammation. “Our research focuses on discovering new ways to prevent heart muscle death and reduce injury after a heart attack. Our ultimate goal is to discover new drugs that can reduce damage and increase healing,” said Dr. Lin.

Masonic Medical Research Institute

Credit: Property of the Masonic Medical Research Institute

UTICA, NY — In the United States, an individual will experience a heart attack every 40 seconds (CDC.gov). As a result of this damage, the body mounts an inflammatory response in an attempt to heal the injury. However, while initially protective, over time, excessive inflammation can actually cause even more damage to the tissue, contributing to heart muscle cell death and to an overall weakening of the heart itself. Dr. Zhiqiang Lin, Assistant Professor at the Masonic Medical Research Institute (MMRI), along with his colleagues, are actively investigating heart disease and inflammation. “Our research focuses on discovering new ways to prevent heart muscle death and reduce injury after a heart attack. Our ultimate goal is to discover new drugs that can reduce damage and increase healing,” said Dr. Lin.

To support this work, Dr. Lin was recently awarded a $3.2 million grant from the National Institutes of Health (NIH), the first grant, of what will hopefully be many, for this junior investigator. The project will study the effects of two major genes in the heart: YAP and IRF2BP2, both of which are required for normal growth and survival of heart cells. Heart attacks are triggered by coronary artery disease, a condition caused by excessive plaque buildup of fatty deposits, leading to a narrowing of the arteries (atherosclerosis). “One of the most crucial steps to save someone suffering a heart attack is to re-establish blood flow to the arteries, a process called reperfusion. Unfortunately, this same process also triggers an inflammatory response to the heart. The goal of my project is to understand whether delivery of YAP and/or IRF2BP2 directly to the heart during the reperfusion process can help establish blood flow but reduce cardiac inflammation, thereby further the heart recovery process with less overall damage,” said Dr. Lin.

This project will be undertaken in collaboration with Dr. Jason McCarthy, Associate Professor at MMRI, who specializes in the development of cell-targeted therapies. “Our aim is to work with Dr. Lin to create nano-sized vehicles that will deliver modified RNA (mRNA) specifically to the heart muscle cells. The specialized delivery will ensure that the therapy goes directly to the injury site, without affecting other areas of the heart or body,” said Dr. McCarthy, “This technology has the potential to significantly improve the quality of life for patients who have suffered a heart attack.”

“Over the next 5 years – the duration of the NIH grant – my lab will continue to delve deeper into understanding the processes of heart recovery post-infarct. This grant makes it possible for us to have the time, resources, and talent to help resolve these exciting research questions,” said Dr. Lin.

###

MMRI is dedicated to scientific research that improves the health and quality of life for all. We strive to conduct high quality research aimed at developing a deep understanding of diseases and generating innovative cures and treatments. For more information about MMRI, please visit mmri.edu or find us on social media!



Share12Tweet7Share2ShareShareShare1

Related Posts

Graphyne

Long-hypothesized ‘next generation wonder material’ created for first time

May 21, 2022
Flower strips next to a conventional wheat field

Organic farming or flower strips – which is better for bees?

May 21, 2022

Haptics device creates realistic virtual textures

May 20, 2022

Researchers unveil a secret of stronger metals

May 20, 2022

POPULAR NEWS

  • Weybourne Atmospheric Observatory

    Breakthrough in estimating fossil fuel CO2 emissions

    46 shares
    Share 18 Tweet 12
  • Hidden benefit: Facemasks may reduce severity of COVID-19 and pressure on health systems, researchers find

    44 shares
    Share 18 Tweet 11
  • Discovery of the one-way superconductor, thought to be impossible

    43 shares
    Share 17 Tweet 11
  • Sweet discovery could drive down inflammation, cancers and viruses

    43 shares
    Share 17 Tweet 11

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Tags

Violence/CriminalsUniversity of WashingtonVaccineVehiclesWeather/StormsWeaponryVirusUrbanizationVaccinesUrogenital SystemVirologyZoology/Veterinary Science

Recent Posts

  • Long-hypothesized ‘next generation wonder material’ created for first time
  • Organic farming or flower strips – which is better for bees?
  • Haptics device creates realistic virtual textures
  • Researchers unveil a secret of stronger metals
  • Contact Us

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
Posting....