Aging-US: A systemic multidisciplinary approach to study aging in sled dogs

Aging-US published “Development of infrastructure for a systemic multidisciplinary approach to study aging in retired sled dogs” which reported that canines represent a valuable model for mammalian aging studies as large animals with short lifespans, allowing longitudinal analyses within a reasonable time frame.

Moreover, they develop a spectrum of aging-related diseases resembling that of humans, are exposed to similar environments, and have been reasonably well studied in terms of physiology and genetics. To reduce variability even further, the authors have collected a population of 103 retired sled dogs from multiple North American kennels in a specialized research facility named Vaika. In addition, they assess the development of age-related diseases such as arthritis and cancer.

Dr. Andrei V. Gudkov and Dr. Ekaterina L. Andrianova said, “Medical advances during the last century have significantly extended the average lifespan and healthspan of humans.”

While, in large part, this has been through the development of improved treatments for specific diseases, we are also continually gaining insights into the mechanisms of aging itself.

With this growing depth of knowledge, aging is no longer considered an untouchable law of nature but rather a physiological challenge that may be defeated by science and medicine. Thus, extending aging research towards more relevant experimental models is desperately needed.

In this regard, the canine model provides multiple advantages. Compared to mice, the aging of dogs resembles that of humans much more closely. Thus, it is gratifying to see aging studies increasingly performed in canine models.

The use of canines for aging studies works towards the obvious goal of prolonging the healthspan of humans and addresses the potential for extending the healthy years of humans’ closest companions – domestic dogs.

The Gudkov/Andrianova Research Team concluded in their Aging-US Research Output that their ongoing program will generate a large volume of data covering, in a longitudinal fashion, multiple parameters related to the general health, physical fitness, immune status, cognitive function, and somatic cell genetic and epigenetic changes of 103 Vaika-resident retired sled dogs.

They expect that these analyses will allow us to characterize the mechanism and regulation of canine aging, identify parameters and biomarkers suitable for assessment of biological age, and define factors that may act as aging accelerators or decelerators. This should allow robust estimation of the efficacy of anti-aging treatments in future trials based on biomarker responses without waiting for animals to reach their ultimate lifespan.

Iron is intimately associated with aging, and control of body iron stores may be an important way to extend human lifespan.”

Full Text – https://www.aging-us.com/article/203600/text

Correspondence to: Andrei V. Gudkov email: [email protected] and Ekaterina L. Andrianova email: [email protected]

Keywords: canine, senescence, frailty, longevity, healthspan

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research as well as topics beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, cancer, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR among others), and approaches to modulating these signaling pathways.

To learn more about Aging-US, please visit http://www.Aging-US.com or connect with @AgingJrnl

Aging-US is published by Impact Journals, LLC please visit http://www.ImpactJournals.com or connect with @ImpactJrnls

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FEATURED NOBEL ARTICLES

• Elizabeth Blackburn, a member of the Editorial Board of Aging, won the Nobel Prize in Physiology or Medicine 2009, while being a member of the board. Elizabeth Blackburn co-authored a paper published in the first (inaugural) issue of Aging.

• Andrew V. Schally, Nobel Prize Laureate, published his paper in Aging.

• Shinya Yamanaka won the Nobel Prize in Physiology and Medicine 2012. Shinya Yamanaka co-authored a paperpublished in Aging.

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